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Project on Government Oversight

POGO Statement Regarding Potential Dangerous Interaction Between Seroquel and Methadone

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July 19, 2011

The Project On Government Oversight just sent a letter about veteran's safety to FDA Commissioner Margaret Hamburg.  In that letter, we asked Dr. Hamburg, once again, to notify patients and prescribers about the potential dangerous interaction between Seroquel and methadone.  Both of these drugs are now widely prescribed to veterans suffering from post-traumatic stress disorder.  We first notified the FDA of this problem back in October.  The FDA has taken an initial step to change the label for Serquel, but has not issued an action alert to doctors.


Founded in 1981, the Project On Government Oversight (POGO) is a nonpartisan independent watchdog that champions good government reforms. POGO’s investigations into corruption, misconduct, and conflicts of interest achieve a more effective, accountable, open, and ethical federal government.

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